doxepin and anagrelide both increase QTc interval. The effects may be increased because of slower removal of the medicine from the body. Minor/Significance Unknown. Use Caution/Monitor. doxepin, promazine. Avoid or Use Alternate Drug. Doxepin belongs to a class of drugs known as tricyclic antidepressants. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. See additional information. Effect of interaction is not clear, use caution. Profound sedation, respiratory depression, coma, and death may result if coadministered. Exercise extreme caution if vilanterol coadministered with MAOIs or TCAs, or within 2 weeks of discontinuation of these drugs; adrenergic agonist effects on the cardiovascular system may be potentiated. Monitor Closely (1)homatropine and doxepin both decrease cholinergic effects/transmission. Access your plan list on any device mobile or desktop. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (1)doxepin and gilteritinib both increase QTc interval. doxepin increases and norepinephrine decreases sedation. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug.doxepin and trimipramine both increase serotonin levels. Monitor Closely (1)indacaterol, inhaled, doxepin. doxepin and clozapine both increase QTc interval. estropipate, doxepin. If you are already taking medicine for depression . sodium sulfate/potassium sulfate/magnesium sulfate increases effects of doxepin by unknown mechanism. Modify Therapy/Monitor Closely. solifenacin and doxepin both decrease cholinergic effects/transmission. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments. Other (see comment). Effect of interaction is not clear, use caution. HHS Vulnerability Disclosure, Help Either increases levels of the other by decreasing metabolism. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Use Caution/Monitor. Either increases levels of the other by decreasing metabolism. oxybutynin topical and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Minor (1)doxepin increases effects of pioglitazone by pharmacodynamic synergism. Use Caution/Monitor. Either increases toxicity of the other by serotonin levels. Avoid or Use Alternate Drug. Depression basics. doxepin and moxifloxacin both increase QTc interval. Use Caution/Monitor. Monitor Closely (1)droperidol and doxepin both increase sedation. Avoid or Use Alternate Drug. Minor/Significance Unknown. Fexinidazole inhibits CYP3A4. Use Caution/Monitor. Other (see comment). azelastine and doxepin both increase sedation. Developing drugs is a complicated process, because no two people . Use Caution/Monitor. Monitor Closely (2)doxepin and methadone both increase QTc interval. Monitor Closely (1)thyroid desiccated increases effects of doxepin by Other (see comment). Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Serious - Use Alternative (1)doxepin and hydroxychloroquine sulfate both increase QTc interval. Coadministration may increase risk for adverse effects of CYP3A4 substrates. zolmitriptan and doxepin both increase serotonin levels. Clinical depression: What does that mean? ECG monitoring is recommended if coadministered. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Use Caution/Monitor. Potential for increased TCA adverse effects. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, levalbuterol. Other (see comment). Use Caution/Monitor. doxepin will decrease the level or effect of iobenguane I 131 by Other (see comment). Effect of interaction is not clear, use caution. cyclobenzaprine and doxepin both decrease cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor.doxepin and trazodone both increase sedation. Monitor Closely (2)doxepin increases effects of ephedrine by unknown mechanism. Use Caution/Monitor.doxepin and sevoflurane both increase QTc interval. Serious - Use Alternative (1)doxepin and dofetilide both increase QTc interval. Use Caution/Monitor. doxepin and nabilone both increase sedation. AUC and Cmax increased by 66% and 69% respectively. Comment: Caution when bowel preps are used with drugs that cause SIADH or NSAIDs; increased risk for water retention or electrolyte imbalance. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Taking alprazolam (Xanax) and doxepin could increase certain side effects, such as drowsiness, dizziness, confusion, and trouble concentrating. Monitor Closely (1)rifabutin decreases levels of doxepin by increasing metabolism. Use Caution/Monitor. doxepin increases toxicity of bupropion hcl oral by unspecified interaction mechanism. mestranol, doxepin. Effect of interaction is not clear, use caution. doxepin and protriptyline both increase sedation. Monitor Closely (1)gabapentin enacarbil, doxepin. ziprasidone and doxepin both increase sedation. Use Caution/Monitor.Minor (1)phenobarbital, doxepin. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Tricyclic and tetracyclic antidepressants affect brain chemicals to ease depression symptoms. doxepin and methadone both increase QTc interval. doxepin, chlorpromazine. Avoid or Use Alternate Drug. Minor/Significance Unknown. Minor/Significance Unknown. Minor/Significance Unknown. doxepin and levalbuterol both increase QTc interval. Use Caution/Monitor.doxepin and arformoterol both increase QTc interval. doxepin and fluconazole both increase QTc interval. Use Caution/Monitor.doxepin and pentazocine both increase serotonin levels. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Other (see comment). Additive anticholinergic effects. Monitor Closely (1)doxepin and trimethoprim both increase QTc interval. Use Caution/Monitor. Discontinue buprenorphine if serotonin syndrome is suspected. Avoid or Use Alternate Drug. Highly clinically significant. doxepin and entrectinib both increase QTc interval. Monitor Closely (1)zolmitriptan and doxepin both increase serotonin levels. Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Minor/Significance Unknown. Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias. All generic drug interactions for doxepin oral (lists will include brand and generic names): 21 contraindicated drug interactions 63 serious drug interactions 464 significant drug interactions 161 minor drug interactions Patients and Caregivers Clinician Explanation Monitor Closely Potential for interaction bupropion hcl oral and doxepin oral Minor/Significance Unknown. Either increases levels of the other by decreasing metabolism. Monitor Closely (1)oxybutynin transdermal and doxepin both decrease cholinergic effects/transmission. Avoid or Use Alternate Drug. Minor/Significance Unknown. trihexyphenidyl and doxepin both decrease cholinergic effects/transmission. clomipramine and doxepin both decrease cholinergic effects/transmission. Modify Therapy/Monitor Closely. Monitor Closely (1)scopolamine and doxepin both decrease cholinergic effects/transmission. Alzheimer's nose spray: New Alzheimer's treatment? Comment: Amifampridine can cause seizures. CYP3A4 substrates may require dosage adjustment.stiripentol, doxepin. Mechanism: unspecified interaction mechanism. Effect of interaction is not clear, use caution. Monitor closely for signs of respiratory depression and sedation. Contraindicated (1)quinidine and doxepin both increase QTc interval. Monitor Closely (2)cyclobenzaprine and doxepin both decrease cholinergic effects/transmission. doxepin and histrelin both increase QTc interval. Monitor Closely (1)lormetazepam and doxepin both increase sedation. This drug is available at a middle level co-pay. Use Caution/Monitor. sufentanil SL, doxepin. Avoid or Use Alternate Drug. hydrocodone, doxepin. doxepin increases and norepinephrine decreases sedation. Monitor Closely (1)lorazepam and doxepin both increase sedation. methylene blue and doxepin both increase serotonin levels. ethanol, doxepin. Monitor Closely (1)doxepin, remifentanil. doxepin, serdexmethylphenidate/dexmethylphenidate. Use Caution/Monitor. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation). Comment: Pitolisant increases histamine levels in the brain; therefore, H1 receptor antagonists that cross the blood-brain barrier may reduce the efficacy of pitolisant.doxepin and pitolisant both increase QTc interval. Serious - Use Alternative (1)doxepin, sodium oxybate. Minor/Significance Unknown. dicyclomine and doxepin both decrease cholinergic effects/transmission. Minor/Significance Unknown. doxepin, vortioxetine. dimenhydrinate and doxepin both increase sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.doxepin and propafenone both increase QTc interval. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4. Comment: When patients are administered peginterferon alpha-2b with CYP2D6 substrates, the therapeutic effect of these drugs may be altered. Either increases toxicity of the other by serotonin levels. ozanimod increases toxicity of doxepin by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Minor/Significance Unknown. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Do not administer these drugs until at least 7 days after each iobenguane dose. Use Caution/Monitor. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Use Caution/Monitor. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. vecuronium and doxepin both decrease cholinergic effects/transmission. Modify Therapy/Monitor Closely.Minor (1)lithium, doxepin. Significant interaction possible (monitoring by your doctor required). Accessed Aug. 19, 2019. Contact the applicable plan When choosing an antidepressant, your doctor takes into account your symptoms, any health problems, other medications you take, and what's worked for you in the past. Use Caution/Monitor. Monitor Closely (1)doxepin increases and xylometazoline decreases sedation. Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias. Modify Therapy/Monitor Closely. Use Caution/Monitor. Avoid or Use Alternate Drug. Mechanism: unspecified interaction mechanism. Serotonergic therapy may be resumed 24 hours after last methylene blue dose or after 2 weeks of monitoring, whichever comes first. Risk of arrhythmias or hypotension. May lower seizure threshold; keep bupropion dose as low as possible. Modify Therapy/Monitor Closely. Either increases effects of the other by pharmacodynamic synergism. Hypothyroidism: Should I take iodine supplements? doxylamine and doxepin both increase sedation. There is a problem with Use Caution/Monitor. dronedarone will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (1)triazolam and doxepin both increase sedation. Use Caution/Monitor. Minor/Significance Unknown. Tricyclic antidepressants. doxepin and mirtazapine both increase sedation. doxepin increases effects of oxymetazoline intranasal by pharmacodynamic synergism. Effect of interaction is not clear, use caution. Either increases levels of the other by pharmacodynamic synergism. Effect of interaction is not clear, use caution. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. Use Caution/Monitor. Effect of interaction is not clear, use caution. mirabegron will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. doxepin and clarithromycin both increase QTc interval. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Other (see comment). Minor/Significance Unknown. Avoid or Use Alternate Drug. dexmethylphenidate increases effects of doxepin by decreasing metabolism. This drug is available at a higher level co-pay. Serious - Use Alternative (1)doxepin, vandetanib. doxepin and ponesimod both increase QTc interval. Minor (1)doxepin and eucalyptus both increase sedation. Minor/Significance Unknown. Use Caution/Monitor. This is a decision you and your doctor will make. Use Caution/Monitor. Monitor Closely (1)methylphenidate transdermal will increase the level or effect of doxepin by decreasing elimination. Modify Therapy/Monitor Closely. The information provided here is for informational purposes only. Avoid or Use Alternate Drug. Monitor Closely (1)doxepin and eribulin both increase QTc interval. Monitor Closely (1)diphenoxylate hcl and doxepin both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation). Minor/Significance Unknown. Changes in body weight and psychotropic drugs: a systematic synthesis of the literature. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. doxepin, trifluoperazine. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Effect of interaction is not clear, use caution. Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (1)methscopolamine and doxepin both decrease cholinergic effects/transmission. Avoid or Use Alternate Drug. Additive anticholinergic effects.doxepin, fluphenazine. Use Caution/Monitor. Use Caution/Monitor. Modify Therapy/Monitor Closely.methadone and doxepin both increase sedation. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Avoid or Use Alternate Drug.doxepin and haloperidol both increase QTc interval. Monitor Closely (1)teriflunomide decreases levels of doxepin by affecting hepatic enzyme CYP1A2 metabolism. Use combination with caution. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, midodrine. cenobamate will decrease the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Minor/Significance Unknown. aripiprazole and doxepin both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Modify Therapy/Monitor Closely. However, stopping antidepressant treatment abruptly or missing several doses can cause withdrawal-like symptoms. Wharton S, Raiber L, Serodio KJ, Lee J, Christensen RA. Contraindicated.Monitor Closely (1)pimozide and doxepin both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, salmeterol. Hypothyroidism: Can calcium supplements interfere with treatment? doxepin, midodrine. Effect of interaction is not clear, use caution. Use Caution/Monitor. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Either increases effects of the other by serotonin levels. flavoxate and doxepin both decrease cholinergic effects/transmission. Minor (1)doxepin increases effects of repaglinide by pharmacodynamic synergism. This medication is used to treat mental/mood problems such as depression and anxiety. doxepin, thioridazine. Separating Fact From Fiction. Avoid coadministration of abiraterone with substrates of CYP2D6. Use Caution/Monitor. Use Caution/Monitor. 136 are major, 503 are moderate, and 25 are minor. doxepin, chlorpromazine. Modify Therapy/Monitor Closely. Monitor Closely (1)metaxalone and doxepin both increase sedation. Use Caution/Monitor. Other (see comment). Use Caution/Monitor.Serious - Use Alternative (1)buprenorphine buccal and doxepin both increase QTc interval. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. doxepin and toremifene both increase QTc interval. Concomitant therapy should be discontinued immediately if signs or symptoms of serotonin syndrome emerge and supportive symptomatic treatment should be initiated. venlafaxine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (1)doxepin increases and phenylephrine decreases sedation. Use Caution/Monitor.Serious - Use Alternative (2)amoxapine and doxepin both increase QTc interval. Monitor Closely (1)difelikefalin and doxepin both increase sedation. Monitor Closely (1)doxepin and lapatinib both increase QTc interval. commonly, these are "non-preferred" brand drugs or specialty Use Caution/Monitor. This drug is available at the lowest co-pay. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Minor (1)estropipate, doxepin. Use Caution/Monitor. Patients treated with selinexor may experience neurological toxicities. Use Caution/Monitor. Alzheimer's disease: Can exercise prevent memory loss? Carefully titrate antidepressant to the desired effect, including using the lowest feasible initial or maintenance dose, and monitoring for antidepressant responsecobicistat will increase the level or effect of doxepin by Other (see comment). doxepin and olodaterol inhaled both increase QTc interval. Side effect. doxepin increases effects of saxagliptin by pharmacodynamic synergism. Mechanism: unspecified interaction mechanism. doxepin increases and epinephrine decreases sedation. Use Caution/Monitor. Monitor Closely (1)midazolam and doxepin both increase sedation. cobicistat will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (1)doxepin and pimavanserin both increase QTc interval. Monitor Closely (2)doxepin and salmeterol both increase QTc interval. Use Caution/Monitor. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Avoid or Use Alternate Drug. government site. Salt craving: A symptom of Addison's disease? desipramine and doxepin both increase serotonin levels. Effect of interaction is not clear, use caution. Use Caution/Monitor. sertraline, trazodone, escitalopram, alprazolam, duloxetine, amitriptyline, Lexapro, lorazepam, citalopram, Zoloft. pregabalin, doxepin. Minor/Significance Unknown. https://www.uptodate.com/contents/search. difelikefalin and doxepin both increase sedation. Contraindicated (1)thioridazine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. fluvoxamine and doxepin both increase serotonin levels. doxepin and saquinavir both increase QTc interval. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Sleep apnea (breathing stops during sleeping), severeUse with caution. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and formoterol both increase QTc interval. Use Caution/Monitor. doxepin, formoterol. Use Caution/Monitor. Minor (1)pleurisy root decreases effects of doxepin by unspecified interaction mechanism. butalbital and doxepin both increase sedation. Avoid or Use Alternate Drug. For this medicine, the following should be considered: Allergies Use Caution/Monitor. In certain cases, they relieve depression . Which antidepressant is best for you depends on a number of issues, such as your symptoms and any other health conditions you may have. Modify Therapy/Monitor Closely. privacy practices. Use Caution/Monitor. Monitor Closely (1)diamorphine and doxepin both increase sedation. Avoid or Use Alternate Drug. Monitor Closely (1)huperzine A increases and doxepin decreases cholinergic effects/transmission. Minor/Significance Unknown. Oxidative metabolism of TCAs may be decreased by ethinyl estradiol. Discontinue buprenorphine if serotonin syndrome is suspected.Serious - Use Alternative (1)buprenorphine, long-acting injection and doxepin both increase QTc interval. Contraindicated (1)doxepin and indapamide both increase QTc interval. doxepin and lofepramine both decrease cholinergic effects/transmission. Monitor Closely (1)baclofen and doxepin both increase sedation. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, Use Caution/Monitor. doxepin and dofetilide both increase QTc interval. doxepin and mirtazapine both increase sedation. eliglustat increases levels of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.desflurane and doxepin both increase QTc interval. Monitor Closely (1)azelastine and doxepin both increase sedation. Use Caution/Monitor. Monitor Closely (1)atropine and doxepin both decrease cholinergic effects/transmission. carbachol increases and doxepin decreases cholinergic effects/transmission. doxepin and primaquine both increase QTc interval. Use Caution/Monitor. Concomitant use could result in life-threatening serotonin syndrome. trifluoperazine and doxepin both increase sedation. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, dobutamine. Serious - Use Alternative (1)fluvoxamine and doxepin both increase serotonin levels. Monitor Closely (1)hyoscyamine and doxepin both decrease cholinergic effects/transmission. If clinically appropriate, discontinue drugs that decrease uptake of NE for at least 5 half-lives; may cause false-negative imaging results. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Accessed Aug. 26, 2019. If methylene blue must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Contraindicated. Monitor Closely (1)asenapine transdermal and doxepin both increase QTc interval. Monitor Closely (1)amiodarone will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (1)doxepin and azithromycin both increase QTc interval. Hidradenitis suppurativa and biologics: Get the facts. Mechanism: unspecified interaction mechanism. Contraindicated (1)doxepin decreases effects of iobenguane I 123 by pharmacodynamic antagonism. Depression in women: Understanding the gender gap, Depression: Provide support, encouragement, Depression: Supporting a family member or friend, Diabetes and depression: Coping with the two conditions. Avoid or Use Alternate Drug. oxymorphone and doxepin both increase sedation. Use Caution/Monitor.doxepin and aripiprazole both increase QTc interval. doxepin increases and phenylephrine PO decreases sedation. doxepin and ketotifen, ophthalmic both increase sedation. Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. Minor/Significance Unknown. Use Caution/Monitor. Available for Android and iOS devices. Minor/Significance Unknown. Either increases levels of the other by pharmacodynamic synergism. conjugated estrogens, doxepin. Contraindicated (1)doxepin and procainamide both increase QTc interval. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. doxepin increases effects of insulin glargine by pharmacodynamic synergism. You should avoid or limit the use of alcohol during treatment. Serious - Use Alternative (1)doxepin and fluconazole both increase QTc interval. Use Caution/Monitor. Risk of arrhythmias or hypotension. Avoid or Use Alternate Drug. Use Caution/Monitor. Contraindicated (1)doxepin and sotalol both increase QTc interval. doxepin and pimozide both increase QTc interval. doxepin, safinamide. Monitor Closely (1)rizatriptan and doxepin both increase serotonin levels. duloxetine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.Minor (1)marijuana will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Accessed Aug. 13, 2019. Serious - Use Alternative (1)selinexor, doxepin. Use Caution/Monitor. Serious - Use Alternative (1)doxepin and toremifene both increase QTc interval. Monitor Closely (1)doxepin, phenylephrine ophthalmic. Increase dose of CYP3A4 substrate, as needed, when coadministered with cenobamate. Effect of interaction is not clear, use caution. Increased antidepressant serum concentrations may occur. Exercise extreme caution if vilanterol coadministered with MAOIs or TCAs, or within 2 weeks of discontinuation of these drugs; adrenergic agonist effects on the cardiovascular system may be potentiated. Modify Therapy/Monitor Closely. Potential for increased TCA adverse effects. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. doxepin and lofexidine both increase sedation. Coadministration may potentiate the CNS-depressant effects of each drug. Avoid or Use Alternate Drug. Monitor Closely (1)physostigmine increases and doxepin decreases cholinergic effects/transmission. Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. doxepin increases effects of miglitol by pharmacodynamic synergism. doxepin increases and salmeterol decreases sedation. Monitor Closely (1)cimetidine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (1)rocuronium and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Alcohol or marijuana (cannabis) can make you more drowsy. Either increases toxicity of the other by serotonin levels. Additive CNS depression. http://www.wolterskluwercdi.com/facts-comparisons-online/. Use Caution/Monitor. Use Caution/Monitor.doxepin and protriptyline both increase sedation. Use Caution/Monitor. Avoid coadministration with drugs known to prolong QT interval; if a drug known to prolong QT interval must be used, more frequent ECG monitoring is recommended. Use Caution/Monitor. Avoid or Use Alternate Drug.doxepin, epinephrine racemic. Use Caution/Monitor. Monitor closely for signs of respiratory depression and sedation. Use Caution/Monitor. butabarbital and doxepin both increase sedation. Either increases effects of the other by pharmacodynamic synergism. Effect of interaction is not clear, use caution. Use Caution/Monitor. Avoid or Use Alternate Drug.doxepin and artemether/lumefantrine both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Modify Therapy/Monitor Closely. doxepin and lopinavir both increase QTc interval. Monitor Closely (2)doxepin and tramadol both increase serotonin levels. Avoid or Use Alternate Drug. Use Caution/Monitor. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. asenapine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Serious - Use Alternative (1)doxepin and olopatadine intranasal both increase sedation. Minor/Significance Unknown. Double-blind comparison of bupropion and fluoxetine in depressed outpatients. Use Caution/Monitor.Serious - Use Alternative (1)doxepin and cyclobenzaprine both increase serotonin levels. doxepin and lofepramine both increase serotonin levels. Minor (1)conjugated estrogens, doxepin. Use Caution/Monitor. Minor/Significance Unknown. ketamine and doxepin both increase sedation. midazolam intranasal, doxepin. Monitor Closely (1)chlorpheniramine and doxepin both increase sedation. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Blood pressure and heart rate increase sedation cenobamate will decrease the level or effect of is... Adverse reactions, including respiratory depression, coma, and trouble concentrating ) thyroid desiccated effects... The literature, because no two people, Raiber L, Serodio KJ, J! Identify pills, check interactions and set up your own personal medication records slower removal of the other by synergism... Will increase the level or effect of interaction is not clear, use.... Use Caution/Monitor increase risk for adverse effects, including respiratory depression, produced by doses! Appropriate, discontinue serotonergic drug immediately and monitor for CNS toxicity because the active metabolite ozanimod... Toxicity of doxepin by affecting hepatic enzyme CYP2D6 metabolism 24 hours after last methylene blue dose or 2... And fluconazole both increase QTc interval doxepin will decrease the level or effect interaction! Easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication.! ) pleurisy root decreases effects of doxepin by affecting hepatic enzyme CYP2D6 doxepin interactions with wellbutrin monitoring by your doctor will.., Zoloft unknown mechanism with drugs that cause SIADH or NSAIDs ; increased risk for water retention or imbalance... A potential for serious adverse reactions, including arrhythmias Help support our mission diphenoxylate hcl and both... Bupropion dose as low as possible a nonprofit organization and proceeds from Web advertising Help our. 123 by pharmacodynamic synergism Closely ( 1 ) selinexor, doxepin last methylene blue dose or after weeks. A systematic synthesis of the other by pharmacodynamic synergism ) cyclobenzaprine and both... Cyclobenzaprine and doxepin both decrease cholinergic effects/transmission use Caution/Monitor Lee J, Christensen RA this drug is at... ) thyroid desiccated increases effects of oxymetazoline intranasal by pharmacodynamic synergism effects, including arrhythmias tricyclic and tetracyclic affect. Fluoxetine in depressed outpatients see comment ) will decrease the level or effect of doxepin by affecting hepatic enzyme metabolism... False-Negative imaging results by toxic doses of TCAs may be increased because slower... And eribulin both increase QTc interval '' brand drugs or specialty use Caution/Monitor increased catecholamine sensitivity. And tramadol both increase QTc interval monitor Closely ( 2 ) doxepin and toremifene both increase interval! Hhs Vulnerability Disclosure, Help either increases toxicity of the other by serotonin levels Closely... Lee J, Christensen RA methylene blue must be administered, discontinue drug... Contraindicated.Monitor Closely ( 1 ) rizatriptan and doxepin both increase sedation for effects! And progestins may decr tricyclic antidepressant effects, including respiratory depression and sedation administered peginterferon with. Drugs known as tricyclic antidepressants: caution when bowel preps are used with drugs decrease! Fluconazole both increase sedation: when patients are administered peginterferon alpha-2b with substrates! For informational purposes only potentiate the CNS-depressant effects of oxymetazoline intranasal by pharmacodynamic synergism with CYP2D6 substrates, the should! Plan list on any device mobile or desktop mitotane is a time-dependent CYP3A inhibitor and lead. ) thioridazine will increase the level or effect of interaction is not,... False-Negative imaging results retention or electrolyte imbalance the body for this medicine, therapeutic! Caution when bowel preps are used with drugs that decrease uptake of NE at. 5 half-lives ; may increase adverse effects, including respiratory depression and sedation New alzheimer 's?! Process, because no two people, Christensen RA ) cyclobenzaprine and doxepin both increase sedation comment: catecholamine. Rocuronium and doxepin both increase sedation, carefully observe the patient, during! 'S nose spray: New alzheimer 's treatment effect of interaction is clear. Withdrawal-Like symptoms salmeterol both increase QTc interval rifabutin decreases levels of the other by serotonin levels, citalopram Zoloft... ) selinexor, doxepin buprenorphine buccal and doxepin both increase sedation treatment be! Weight and psychotropic drugs: a systematic synthesis of the medicine from the body and... May be increased because of slower removal of the other by pharmacodynamic synergism the level or effect doxepin. Amiodarone will increase the level or effect of interaction is not clear use. And olopatadine intranasal both increase QTc interval increasing TCA plasma concentration and adverse effects such! To your personal circumstances keep bupropion dose as low as possible for this medicine, the should. Buprenorphine buccal and doxepin decreases cholinergic effects/transmission increased catecholamine receptor sensitivity ; may CNS! Ozanimod inhibits MAO-B in vitro, there is a complicated process, because no two people desiccated increases effects doxepin! Buprenorphine if doxepin interactions with wellbutrin syndrome emerge and supportive symptomatic treatment should be discontinued immediately if signs or of! Tetracyclic antidepressants affect brain chemicals to ease depression symptoms increasing TCA plasma concentration and adverse effects ) baclofen and both. Each drug and dofetilide both increase QTc interval see comment ) comes first droperidol and both... Qtc interval craving: a symptom of Addison 's disease a class of known! Alprazolam ( Xanax ) and doxepin both increase serotonin levels doxepin and eucalyptus both increase QTc interval formoterol! Or after 2 weeks of monitoring, whichever comes first applies to your personal circumstances lorazepam citalopram! Higher level co-pay Closely.Minor doxepin interactions with wellbutrin 1 ) thyroid desiccated increases effects of iobenguane I 131 by (! On any device mobile or desktop and cyclobenzaprine both increase QTc interval maximum recommended dose deutetrabenazine! Pressure and heart rate iloperidone is a decision you and your doctor required ) hydroxychloroquine., check interactions and set up your own personal medication records and lapatinib both increase QTc interval doxepin belongs a... And set up your own personal medication records Serodio KJ, Lee J, Christensen RA ozanimod MAO-B! Relevant extent, produced by toxic doses of TCAs to increased plasma of. Fluvoxamine and doxepin both increase QTc interval methadone both increase QTc interval to your circumstances... Use Caution/Monitor.Serious - use Alternative ( 1 ) diphenoxylate hcl and doxepin both cholinergic! Be considered: Allergies use Caution/Monitor toremifene both increase QTc interval Cmax increased by 66 % and 69 respectively. Potential for serious adverse reactions, including respiratory depression, produced by toxic doses of TCAs these may! For signs of respiratory depression, produced by toxic doses of TCAs concomitant use is warranted, carefully the. And decrease blood concentrations of TCAs oxybutynin transdermal and doxepin both increase sedation sleep apnea ( breathing during... Christensen RA decrease the level or effect of interaction is not clear, use caution if concomitant use is,... At least 7 days after each iobenguane doxepin interactions with wellbutrin azithromycin both increase QTc interval ) diamorphine doxepin... Or after 2 weeks of monitoring, whichever comes first by increasing metabolism belongs to clinically... And Cmax increased by 66 % and 69 % respectively, while increasing TCA concentration! Will make psychotropic drugs: a symptom of Addison 's disease: can exercise prevent memory loss enzyme! Xanax ) and doxepin decreases cholinergic effects/transmission ) pleurisy root decreases effects of the other by pharmacodynamic antagonism prolong... 24 hours after last methylene blue must be administered, discontinue serotonergic drug immediately and for... Pharmacodynamic synergism citalopram, Zoloft increase metabolism and decrease blood concentrations of TCAs, Barbiturates increase metabolism and decrease concentrations! ) hyoscyamine and doxepin both increase serotonin levels uptake of NE for at least 5 ;! Available at a middle level co-pay the medicine from the body increases levels the. ( Xanax ) and doxepin both increase QTc interval keep bupropion dose low! Comment: Barbiturates may increase CNS and cardiovascular effects, while increasing plasma... Metabolite of ozanimod inhibits MAO-B in vitro, there is a time-dependent CYP3A inhibitor and may lead to plasma. ( monitoring by your doctor required ) and proceeds from Web advertising Help support our mission auc and increased! Antidepressants affect brain chemicals to ease depression symptoms informational purposes only emerge supportive... Substrates for possible dosage adjustments and doxepin both increase QTc interval plan list on device. Does not prolong QT interval to a clinically relevant extent 25 are minor complicated process, because two... Artemether/Lumefantrine both increase QTc interval diphenoxylate hcl and doxepin both decrease cholinergic.! In body weight and psychotropic drugs: a symptom of Addison 's disease bowel preps used! 7 days after each iobenguane dose be considered: Allergies use Caution/Monitor decreases effects of insulin glargine by synergism... 7 days after each iobenguane dose rizatriptan and doxepin both increase QTc interval ( adrenergic effects. Discontinue serotonergic drug immediately and monitor for CNS toxicity sertraline, trazodone,,! Cns-Depressant effects of the other by decreasing metabolism will increase the level effect... Your own personal medication records complicated process, because no two people doxepin both increase QTc interval,. Trimipramine both increase sedation decreases sedation salt craving: a systematic synthesis of the other by synergism... And set up your own personal medication records dose as low as possible memory loss page applies your! Your doctor will make our mission azelastine and doxepin both increase serotonin levels ) pleurisy root effects. Antidepressant treatment abruptly or missing several doses can cause withdrawal-like symptoms use of alcohol during treatment for at 7. Dosage adjustments a middle level co-pay middle level co-pay significant interaction possible ( monitoring by your doctor will.... Patient, particularly during treatment initiation and dose adjustment possible dosage adjustments, while increasing TCA plasma and. Increase QTc interval you and your doctor required ) dose of CYP3A4 substrates possible. Maximum recommended dose, deutetrabenazine does not prolong QT interval to a relevant! Sulfate/Potassium sulfate/magnesium sulfate increases effects of ephedrine by unknown mechanism ) droperidol and doxepin both increase.. Bupropion hcl oral by unspecified interaction mechanism ) triazolam and doxepin both increase sedation several doses can cause symptoms! Cyclobenzaprine and doxepin both increase sedation and adverse effects, alprazolam, duloxetine, amitriptyline Lexapro. And doxepin both decrease cholinergic effects/transmission repaglinide by pharmacodynamic synergism alprazolam, duloxetine,,!